Melior Discovery Collaborative Publications

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 Collaborative Discoveries
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Nanoparticle-based inhibition of vascular endothelial growth factor receptors alleviates osteoarthritis pain and cartilage damage

Kaige Ma, Tiep Pham, Jun Wang, InSug O-Sullivan, Amy DiCamillo, Shiyu Du, Fackson Mwale, Zeba Farooqui, Gina Votta-Velis, Benjamin Bruce, Andre J van Wijnen, Ying Liu, Hee-Jeong Im

Sci Adv. 2024 Feb 16;10(7):eadi5501. doi: 10.1126/sciadv.adi5501. Epub 2024 Feb 14
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A PDK-1 allosteric agonist improves spatial learning and memory in a βAPP/PS-1 transgenic mouse-high fat diet intervention model of Alzheimer’s disease

Quefurth H, Slitt A, DiCamillo A, Surles N, DeBoef B, Lee H-K.

Behav. Brain Res. 2023 Feb 13:438:114183. doi: 10.1016/j.bbr.2022.114183
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Intravenously Administered Ganaxolone Blocks Diazepam-Resistant Lithium-Pilocarpine-Induced Status Epilepticus in Rats: Comparison with Allopregnanolone

Saporito MS, Gruner JA, DiCamillo A, Hinchliffe R, Barker-Haliski M and White HS.

J. Pharmacol. Exp. Therap. 2019 Mar; 368(3):326-337
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Translating Alcohol Research: Opportunities and Challenges

Batman AM, Miles MF

Alcohol Research 2015;37(1):7-14.
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ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice.

Naydenov AV, Horne EA, Cheah CS, Swinney K, Hsu KL, Cao JK, Marrs WR, Blankman JL, Tu S, Cherry AE, Fung S, Wen A, Li W, Saporito MS, Selley DE, Cravatt BF, Oakley JC, Stella N.

Neuron. 2014 Jul 16;83(2):361-71.
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Anticonvulsant activity of pregabalin in the maximal electroshock-induced seizure assay in α2δ1 (R217A) and α2δ2 (R279A) mouse mutants.

Lotarski S, Hain H, Peterson J, Galvin S, Strenkowski B, Donevan S, Offord J.

Epilepsy Res. 2014 Jul;108(5):833-42.
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ADX71441, a novel, potent and selective positive allosteric modulator of the GABA(B) receptor, shows efficacy in rodent models of overactive bladder.

Kalinichev M, Palea S, Haddouk H, Royer-Urios I, Guilloteau V, Lluel P, Schneider M, Saporito M, Poli S.

Br J Pharmacol. 2014 Feb;171(4):995-1006.
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Discovery of high potency, single-chain insulin analogs with a shortened B-chain and nonpeptide linker.

Kaur ZP, Ochman AR, Mayer JP, Gelfanov VM, DiMarchi RD.

ACS Chem Biol. 2013 Aug 16;8(8):1822-9.
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Possible therapeutic effect of trilostane in rodent models of inflammation and nociception.

Tung D, Ciallella J, Hain H, Cheung PH, Saha S.

Curr Ther Res Clin Exp. 2013 Dec;75:71-6.